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. 2015 Mar 24;6(11):8552–8566. doi: 10.18632/oncotarget.3298

Figure 4. Transcriptome analysis of fibroblasts from Nd2-mutant and control mice microarray.

Figure 4

A. Immunoblotting of total p38MAPK and p-p38MAPK of fibroblasts from 12-month-old Nd2-mutant and control mice. Lysates were pooled from fibroblasts of three different mice. RPL26 was used as loading control. B. Total RNA was extracted from fibroblasts of Nd2-mutant and control mice and subjected to transcriptome analysis using MouseRef-8 v2.0 Expression BeadChips. Significantly enriched downregulated genes were grouped by pathways using DAVID Bioinformatics Resources 6.7. C. Map of genes interactions downregulated in “pathways in cancer” and “MAPK signaling pathway” generated by STRING 9.1 analysis.