Skip to main content
. 2015 Mar 24;6(11):8593–8605. doi: 10.18632/oncotarget.3309

Figure 4. DMBA-TPA treatment results in accelerated growth of squamous derived neoplasia in Inv-Dsg2/Ptc1+/LacZ mice.

Figure 4

A. Macroscopic tumor formation is observed in all mice after DMBA-TPA treatment. B. Histological analysis reveals papillomas and in situ carcinomas in all genotypes (scale bars = 100 and 250 microns, respectively). C. Tumor incidence is depicted as percentage of mice exhibiting tumors. D. The average tumor diameter was determined for all mice. E. Tumor multiplicity represents the average number of tumors per genotype. F. Tumor burden, accounts for size and number of tumors, is represented as the sum of tumors x size (Σ). WT (n = 11); Ptc1+/lacZ (n = 5); Inv-Dsg2 (n = 10); Inv-Dsg2/Ptc1+/lacZ (n = 8). The data are shown as the mean ± SEM. *p < 0.05; **p < 0.01; t-test.