Figure 7. Animal survival studies after CED treatment with cetuximab-IONPs in a human GBM neurosphere model.
Mice intracranially implanted with EGFR-expressing human GBM neurospheres were subjected to CED with cetuximab-IONPs. (A) T2 weighted MRI before CED and days 0, 19, 36, 50, 64, 78, 92, 106, 119, 134, 146 after CED revealed the presence of cetuximab-IONPs (black arrow) and a very small tumor (top and bottom, upper panel, white arrow) in comparison with control mouse (top and bottom, lower panel). (B) Kaplan-Meier survival curve of athymic nude mice intracranially implanted with human GBM neurospheres and CED treated with control, cetuximab, and cetuximab-IONPs. Statistical significance was estimated by log-rank method (P<0.005).