TABLE 3. Metastasis observed with K5+/K19− and K5+/K19+ stem/progenitor cells with different combination.
Cell Line | Metastasis first appeared in mice | No. of mice that formed lung metastasis by 32 weeks | No. of mice that formed liver metastasis by 32 weeks |
---|---|---|---|
K5+/K19− mRas/mp53/wtErbB2 | 31st week | 6/10 | 0/10 |
K5+/K19+ mRas/mp53/wtErbB2 | 25th week | 10/10 | 0/10 |
K5+/K19− mRas/mp53/wtEGFR | 26th week | 5/7 | 2/7 |
K5+/K19+ mRas/mp53/wtEGFR | 11th week | 10/10 | 0/10 |