Table 1. Tumor formation in Ptch+/− mice after application of 5-aza-dC.
| age at 5-aza-dC application | n | age range; median (days) | mice with RMS1 | median LT2 of RMS (days) | RMS3/mouse (mean ± SEM) | mice with cystic tumors4 | others |
|---|---|---|---|---|---|---|---|
| E9.5–E11.5 | 25 | 46–230; 101 | 23 (92%) | 50 | 3.5 ± 0.49 | 6 (24%) | 25 |
| – | 21 | 93–272; 161 | 20 (95%) | 98 | 2.6 ± 0.29 | 6 (29%) | 0 |
1
palpable RMS only
2
latency time of the first palpable RMS
3
palpable and non-palpable RMS
4
see [13]
5
1 mouse suffered from rectum prolapse, 1 developed a non-palpable RMS