Figure 1. Inhibition of Src family kinases (SFK) enhances Claudin-2 expression in breast cancer cells.

Immunoblot analysis for Claudin-2 expression in both human breast (BRC31, MDA-MB-231) (A) or in a liver metastatic variant (2776) derived from the mouse 4T1 breast cancer cell line (B) treated with vehicle or two SFK inhibitors (Dasatinib and PP2). α-Tubulin served as a loading control and pSFK/Src blots revealed the efficacy of the SFK kinase inhibitors.