Figure 5. TRAIL-R2 status does not affect osteolysis in MDA-MB-231-BO-derived bone lesions.

Tumor-burdened mice were imaged weekly by in vivo micro-CT. Baseline and follow-up scans were registered (A) and relative changes in BMD values were quantified (B). Histological sections were stained for TRAP activity and imaged (C). Images show a representative image of Ctrl-shRNA injected mice and TRAP stained images for both hind limbs which developed tumors in the R2-shRNA group. Graphs represent average values from tumor-burdened limbs ± SD.