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. 2015 Mar 25;6(11):9502–9516. doi: 10.18632/oncotarget.3321

Figure 7. Overexpression of TRAIL-R2 in MDA-MB-231 cells upregulates the expression of CXCR4 and enhances migration towards SDF-1.

Figure 7

Expression of TRAIL-R2, CXCR4 and EGFR in control cells (pCR3.1) and cells overexpressing the long (R2-long) or short (R2-short) isoforms was assessed by flow cytometry in non-permeabilized and permeabilized cells and percent of stained cells (A) and staining intensities per cell (B), relative to non-specific antibody controls, were quantified. (C) Cells were analyzed in regard to their migration capacity towards SDF-1 in a trans-well assay. Graphs represent average values ± SD. (A–B: n = 3, C: n = 4) (*p < 0.05, **p < 0.01 ***p < 0.001).