Table 2. Genotypes of MTRR, MTHFR, MTR and TS polymorphisms and gastric cancer patients’ survival.
| Genetic model | Genotypes | patients | Deaths | MST (months) | log-rank P | HR (95%CI)a |
|---|---|---|---|---|---|---|
| MTRR rs1801394 A66G | ||||||
| Codominant model | AA | 489 | 242 | 51 | 0.014 | 1.00 |
| GA | 347 | 151 | 80 | 0.838(0.684–1.028) | ||
| GG | 49 | 14 | 87b | 0.500(0.291–0.856) | ||
| Dominant model | AA | 489 | 242 | 51 | 0.022 | 1.00 |
| GA/GG | 396 | 165 | 97 | 0.793(0.651–0.967) | ||
| Recessive model | AA/GA | 836 | 393 | 65 | 0.019 | 1.00 |
| GG | 49 | 14 | 87b | 0.537(0.315–0.915) | ||
| MTHFR rs1801131 A1298C | ||||||
| Codominant model | AA | 640 | 301 | 65 | 0.090 | 1.00 |
| CA | 236 | 110 | 63 | 0.985(0.792–1.225) | ||
| CC | 28 | 7 | 81b | 0.444(0.210–0.940) | ||
| Dominant model | AA | 640 | 301 | 65 | 0.429 | 1.00 |
| CA/CC | 264 | 117 | 89 | 0.918(0.742–1.137) | ||
| Recessive model | AA/CA | 876 | 411 | 65 | 0.042 | 1.00 |
| CC | 28 | 7 | 81b | 0.446(0.211–0.942) | ||
| MTHFR rs1801133 C677T | ||||||
| Codominant model | CC | 313 | 151 | 60 | 0.793 | 1.00 |
| TC | 438 | 200 | 78 | 0.940(0.761–1.161) | ||
| TT | 141 | 63 | 63 | 0.918(0.684–1.231) | ||
| Dominant model | CC | 313 | 151 | 60 | 0.51 | 1.00 |
| TC/TT | 579 | 263 | 74 | 0.935(0.766–1.143) | ||
| Recessive model | CC/TC | 751 | 351 | 65 | 0.708 | 1.00 |
| TT | 141 | 63 | 63 | 0.951(0.727–1.244) | ||
| MTR rs1805087 A2756G | ||||||
| Codominant model | AA | 684 | 314 | 52 | 0.041 | 1.00 |
| GA | 149 | 69 | 88 | 1.033(0.796–1.341) | ||
| GG | 7 | 0 | 75b | 0 | ||
| Dominant model | AA | 688 | 317 | 67 | 0.038 | 1.00 |
| GA/GG | 149 | 69 | 70 | 0.972(0.749–1.261) | ||
| Recessive model | AA/GA | 830 | 386 | 65 | 0.053 | 1.00 |
| GG | 7 | 0 | 75b | 0.049(0.001–3.620) | ||
| TYMS 5-UTR 2R > 3R | ||||||
| Codominant model | 2R2R | 43 | 24 | 35 | 0.279 | 1.00 |
| 2R3R | 276 | 113 | 70 | 0.807(0.522–1.248) | ||
| 3R3R | 51 | 27 | 78 | 0.732(0.481–1.115) | ||
| Dominant model | 2R/2R | 43 | 24 | 35 | 0.184 | 1.00 |
| 2R3R/3R3R | 794 | 357 | 74 | 0.758(0.501–1.146) | ||
| Recessive model | 2R2R/2R3R | 319 | 154 | 62 | 0.216 | 1.00 |
| 3R3R | 518 | 227 | 78 | 0.880(0.717–1.080) | ||
| TYMS 3-UTR 6bp ins/del | ||||||
| Codominant model | I/I | 61 | 30 | 46 | 0.682 | 1.00 |
| D/I | 410 | 193 | 63 | 0.948(0.645–1.393) | ||
| D/D | 413 | 187 | 77 | 0.880(0.598–1.294) | ||
| Dominant model | I/I | 61 | 30 | 46 | 0.63 | 1.00 |
| DI/DD | 823 | 380 | 70 | 0.913(0.630–1.324) | ||
| Recessive model | II/DI | 471 | 223 | 63 | 0.407 | 1.00 |
| D/D | 413 | 187 | 77 | 0.922(0.759–1.119) | ||
a
Adjusted for age and sex.
b
Mean survival time was provided when MST could not be calculated.