Table 4. The effects of gene-gene interactions on the survival of gastric cancer patients.
| combined genotypes | patients | Deaths | MST (months) | P | HR (95%CI)a |
|---|---|---|---|---|---|
| MTHFR 1298A>C and TS5-UTR 2R>3R | |||||
| MTHFR 1298AA+TS5-UTR 2R2R | 26 | 16 | 30 | 0.111 | 1.00 |
| MTHFR 1298AA+TS5-UTR 2R2R+2R3R | 565 | 262 | 67 | 0.790 | 0.636(0.3840–1.054) |
| MTHFR 1298CC+CA+TS5-UTR 2R2R | 14 | 8 | 33 | 0.510 | 0.752(0.322–1.757) |
| MTHFR 1298CC+CA+TS5-UTR2R2R+2R3R | 225 | 91 | 98 | 0.022 | 0.536(0.315–0.913) |
| MTRR 66A>G and MTR 2756A>G | |||||
| MTRR 66AA+MTR 2756AA | 373 | 187 | 50 | 0.016 | 1.00 |
| MTRR 66AA+MTR 2756GG+GA | 75 | 30 | 69b | 0.082 | 0.710(0.483–1.044) |
| MTRR 66GG+GA+MTR 2756AA | 286 | 112 | 75 | 0.006 | 0.720(0.569–0.910) |
| MTRR 66GG+GA+MTR 2756GG+GA | 70 | 38 | 52 | 0.730 | 1.063(0.750–1.507) |
| MTRR 66A>G and MTR 2756A>G | |||||
| MTRR 66AA+MTR 2756AA | 373 | 187 | 50 | 0.094 | 1.00 |
| MTRR 66AA+MTR 2756GA | 69 | 30 | 65b | 0.223 | 0.787(0.535–1.157) |
| MTRR 66GA+MTR 2756AA | 255 | 106 | 98 | 0.034 | 0.773(0.609–0.981) |
| MTRR 66GA+MTR 2756GA | 57 | 32 | 44 | 0.580 | 1.112(0.764–1.617) |
a
Adjusted for age and sex.
b
Mean survival time was provided when MST could not be calculated.