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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nat Med. 2015 Jun 8;21(7):808–814. doi: 10.1038/nm.3871

Figure 1. Candida spp. gastrointestinal colonization levels in antibiotic-treated adult mice, germ-free adult mice, and infant-adolescent mice.

Figure 1

CA SC5314 colonization levels in (a) adult C57/BL6 mice (Harlan) pre-treated with (streptomycin, STREP; penicillin G, PCN; penicillin and streptomycin, PS; clindamycin, C; or metronidazole, M) or without antibiotics and then oral gavaged with CA. Mice continued on antibiotic water throughout the experiment. n=8. (b) Adult germ-free mice (C57/BL6). n=4. (c) Postnatal day (P)14, P28, and P42 mice (C57/BL6, Harlan). n=4. (d, e) Colonization levels of (d) other CA strains and (e) other Candida spp. Adult C3H/HeN mice (Harlan) pre-treated with or without antibiotics in the drinking water for 5 days then oral gavaged with (d) CA or other (e) Candida spp. Mice continued on antibiotic water throughout the experiment. n=4. Candida levels were measured every 7 days (a-c) or 21 days (d-e) after oral gavage. Points represent results from individual animals. Horizontal lines with bars represent the median with interquartile range.