Table 3.
Characteristics of the 28 patients with a pre-diagnosis symptom interval >24 months
| Patient no. |
PSI (months) |
Sex/ Race |
Age at diagnosis (years) |
Tumor site | Symptoms/Signsa | PD | GTR | Seizure | Shunt | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 24.01 | M/B | 15.0 | Hypothalamus | Headache Lethargy |
Y | ||||
| 2 | 24.01 | F/W | 8.3 | Thalamus | R hand weakness Irregular gait Ataxia Switched R to L hand |
Y | ||||
| 3 | 24.05 | F/W | 14.4 | Cerebellum | Headache Seizure |
Y | Y | Y | ||
| 4 | 24.05 | F/W | 5.0 | Cerebellum | Headache N&V |
Y | ||||
| 5 | 24.05 | M/W | 15.7 | Temporal lobe | Seizure Headache |
Y | Y | Dead | ||
| 6 | 24.05 | F/W | 5.9 | Spinal cord | Neck pain | Y | ||||
| 7 | 27.57 | F/W | 12.6 | Parietal lobe | L sensory seizure | Y | ||||
| 8 | 27.83 | M/W | 3.3 | Hypothalamus/optic chiasm | Trouble locating objects Walked into walls Irritability Drooling |
Y | Dead | |||
| 9 | 29.15 | F/W | 2.7 | Posterior fossa | Strabismus Ptosis of L eye Head tilt Drooling Dragging L foot |
Y | ||||
| 10 | 31.94 | M/B | 12.3 | Posterior fossa | Headache Worsening headache |
Y | ||||
| 11 | 34.93 | F/B | 7.6 | Thalamus | Headache Vomiting |
Y | ||||
| 12 | 36.02 | F/W | 6.0 | Posterior fossa | Clumsiness Headache |
Y | ||||
| 13 | 36.02 | M/B | 1.5 | Temporal lobe | Seizure Headache Diplopia |
Y | ||||
| 14 | 36.05 | F/B | 16.8 | Posterior fossa | Headache | Y | Y | |||
| 15 | 37.07 | F/B | 3.6 | Hypothalamus, optic pathway | Nystagmus | |||||
| 16 | 39.11 | F/W | 13.3 | Posterior fossa | Headache Vomiting |
Y | ||||
| 17 | 42.07 | F/W | 12.8 | Temporal lobe | Dizzy Spells Increased sleeping |
Y | ||||
| 18 | 42.07 | M/W | 16.0 | Temporal lobe | Headache Visual problems |
|||||
| 19 | 46.05 | M/W | 14.2 | Hypothalamus | Diplopia Headache N&V Personality change |
Y | Y | |||
| 20 | 47.63 | M/W | 8.3 | Brainstem/medulla | Intentional tremor | Y | Y | Dead | ||
| 21b | 49.54 | M/W | 7.1 | Hypothalamus | Poor appetite Poor weight gain Leg injuryc |
Y | Y | |||
| 22 | 58.72 | F/B | 12.3 | Dorsally exophytic brain stem | Headache Photophobia Vomiting |
Y | Y | |||
| 23 | 58.82 | M/W | 4.9 | Posterior fossa | Sacral dimple | Y | ||||
| 24 | 72.11 | F/W | 12.6 | Thalamus | Headache R arm weakness R face and tongue weakness |
Y | ||||
| 25 | 99.38 | M/W | 15.5 | Hypothalamus | Precocious puberty | Y | ||||
| 26 | 107.7 0 | F/W | 12.0 | Parietal lobe | L leg shaking L arm shaking Seizure |
Y | Y | |||
| 27 | 128.5 5 | M/W | 11.9 | Posterior fossa | Seizure Violent episode |
Y | Y | |||
| 28 | 131.0 5 | F/W | 15.9 | Spinal cord | Scoliosis |
PSI, pre-diagnosis symptom interval; DX, diagnosis; SX, symptom; PD, progressive disease; GTR, gross total resection; M, male; B, Black; R, right; L, left; F, female; W, white; Y, yes; N&V, nausea and vomiting.
a
Symptoms/signs are listed in the order reported or observed.
b
The only patient in this group with metastatic disease.
c
Not further described.