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Schematic mechanism of action of rosiglitazone-activated PPARγ in neuroprotection. Rosiglitazone enters the nucleus and binds PPARγ. The activated PPARγ binds the NF-α1 promoter to activate transcription. The NF-α1 mRNA is consequently translated and the protein is secreted. It then binds a cognate receptor and activates the ERK and AKT pathways leading to an increase in BCL-2 expression which mediate neuroprotection by inhibition of caspases.
