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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Neurochem. 2015 Jun 3;134(3):445–454. doi: 10.1111/jnc.13148

Figure 5.

Figure 5

Effect of buffer, cocaine and 3-iodotyrosine on repeated stimulations. The representative concentrations vs time profiles are shown for the first stimulation (black) and the fifth stimulation (red). A.) Incubation in buffer, 1 min stimulation interval. B.) Incubation in 60 μM cocaine, 1 min stimulation interval. C.) Incubation in 100 μM 3-iodotyrosine, 1 min stimulation interval. D.) Incubation in buffer, 5 min stimulation interval. E.) Incubation in 60 μM cocaine, 5 min stimulation interval. F.) Incubation in 100 μM 3-iodotyrosine, 5 min stimulation interval. The dopamine concentration is larger and the time response is slower in cocaine at the 1st stimulation, while there is no difference in 3-iodotyrosine. Note the concentration scale for cocaine is different from the buffer and 3-iodotyrosine groups.