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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Addict Biol. 2015 Jan 8;21(2):360–373. doi: 10.1111/adb.12206

Fig. 1.

Fig. 1

Experimental procedure. (a) Following a baseline period during which cocaine self-administration was only available during daily 2 h (0900 to 1100 h) cocaine vs food choice sessions, monkeys (N=4) were subsequently given daily access to cocaine during both “choice” sessions and “extended access” sessions lasting 20 h (noon to 0800 h). During extended-access sessions, monkeys could respond for 0.1 mg/kg/injection cocaine under a FR 10/time out 15-min schedule of reinforcement. After 14 days of extended cocaine access, 3.2 or 10 mg/kg nor-BNI was administered intramuscularly (IM). Extended-access conditions were continued for an additional 14 days following nor-BNI treatment. (b) Following a baseline period during which cocaine self-administration was only available during daily 2 h cocaine vs food choice sessions, monkeys (N=2) were administered 3.2 mg/kg nor-BNI 24 h before initiation of both “choice” sessions and “extended access” sessions. Extended-access conditions were implemented for 14 days following nor-BNI treatment.