Table 1.
Nor-BNI (3.2 or 10.0 mg/kg, IM) treatment effects on group mean (N=4 per group) cocaine intakes (mg/kg) during both the cocaine vs. food choice and the 20-hr extended cocaine access components of the daily session.
Choice session cocaine (mg/kg) | Extended-access cocaine (mg/kg) | Total daily cocaine (mg/kg) | |
---|---|---|---|
Choice session only | 1.25 ± 0.14 | — | 1.25 ± 0.14 |
+ Extended access – 7 D | 1.10 ± 0.21 | 6.15 ± 2.22 | 7.25 ± 2.08 |
+ Extended access – 14 D | 1.20 ± 0.18 | 5.91 ± 1.89 | 7.11 ± 2.00 |
+ 3.2 nor-BNI – 7 days | 1.04 ± 0.23 | 6.41 ± 1.37 | 7.45 ± 1.31 |
+ 3.2 nor-BNI – 14 days | 1.18 ± 0.11 | 6.33 ± 1.41 | 7.51 ± 1.30 |
Choice session only | 1.19 ± 0.16 | — | 1.19 ± 0.16 |
+ Extended access – 7 D | 1.06 ± 0.22 | 7.32 ± 0.53 | 8.38 ± 0.67 |
+ Extended access – 14 D | 1.08 ± 0.24 | 6.96 ± 0.67 | 8.04 ± 0.81 |
+ 10.0 nor-BNI – 7 days | 1.18 ± 0.09 | 7.08 ± 0.51 | 8.27 ± 0.48 |
+ 10.0 nor-BNI – 14 days | 1.21 ± 0.15 | 5.83 ± 1.48 | 7.05 ± 1.38 |
Data represent group mean ± 95% confidence limit cocaine intakes of the last 3 days means of each 7-day experimental condition for individual monkey.