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. 2015 Mar 12;6(12):10102–10115. doi: 10.18632/oncotarget.3546

Figure 1. Histologic features of liver tumors developed in PIK3CA/Yap mice as assessed by H&E staining.

Figure 1

(A) Macroscopic appearance of livers from mice injected wih PIK3CAH1047R and YapS127A (PIK3CA/Yap) mice. (B) Kaplan Meier survival curve of wild-type (WT), PIK3CA1047R and PIK3CA/Yap mouse cohort. (C) Preneoplastic lesion consisting of lipid-rich ballooned hepatocytes located around a hepatic vein (V). (D) Pure hepatocellular carcinoma (HCC) characterized by solid and trabecular growth of mildly atypical lipid-rich neoplastic hepatocytes. The arrow indicates a mitosis. (E) Small mixed tumor consisting of both hepatocellular and cholangiocellular components. The hepatocellular part of the tumor consists of large, lipid-rich cells, mainly situated in the outer part of the tumor. Smaller cells with a high nuclear:cytoplasmic ratio, located in the core of the lesion, constitute the cholangiocellular part of the tumor. (F) Mixed HCC/cholangiocarcinoma (CCA) tumor displaying the presence of the hepatocellular component (left part of the picture) that is adjacent to the cholangiocellular component (right part of the picture). (G) Mixed HCC/CCA tumor with hepatocellular and cholangiocellular constituents intermingled with each other, showing moderate cellular atypia and a limited stroma component. The cholangiocellular component forms duct-like structures (asterisks), whereas the hepatocellular component consists of altered, lipid-rich hepatocytes (indicated by arrows). (H) Pure CCA showing significant cellular atypia. Original magnification: 400X.