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. 2015 Mar 12;6(12):10102–10115. doi: 10.18632/oncotarget.3546

Figure 5. Combined injection of PIK3CAH1047R and a mutant form of Yap that does not bind TEAD transcription factors (YapS127AS94A) abolishes tumor development in mice.

Figure 5

(A) Macroscopic appearance of livers from PIK3CA/YapS127AS94A mice 13 weeks post hydrodynamic injection. (B and C) Lower (B) and higher (C) magnification of PIK3CAH1047R/YapS127AS94A mouse liver showing the absence of tumors, as assessed by Hematoxylin and eosin staining. At higher magnification, the presence of lipid-rich hepatocytes resembling those occurring in mice injected only with PIK3CAH1047R is appreciable. Original magnification: 40X in B; 200X in C.