Figure 5. mPGES-1-deficiency impairs PyMT tumor growth.

(A) Prostanoids PGE₂, PGD₂, PGF₂α, TxB₂, and 6 keto PGF₁α in wildtype (WT; n=8) and mPGES-1^−/− (n = 10) PyMT tumors were measured by LC-MS/MS. Data are means ± SEM. (B) The average number of tumor-bearing mammary glands per mouse is displayed. (C,D) PyMT mice were sacrificed 20 weeks after birth. (C) Tumor burden is defined as the ratio of total tumor mass and mouse body weight. (D) Tumors were categorized and their respective numbers are displayed. (B-D) Data are means ± SEM of 20 WT and 18 mPGES-1^−/− mice. p-values were calculated using student's t-test (C) or two-way ANOVA with Bonferroni's correction (A,B). Asterisks indicate significant differences between experimental groups (*, p ≤ .05, **, p ≤ .01, ***, p ≤ .001).