Table 3. IC₅₀ values for doxorubicin treatment in the presence or absence of salinomycins.

Cell Line	NC-Vectors			FOXO3a-TM Plasmid
	IC50 of Doxa (μg/ml)		Combination Index	IC50 of Doxb (μg/ml)		Combination Index
	Dox	Dox+Sal		Dox	Dox+Sal
HuH-7	0.7769	0.5072***	0.7476	0.6381	0.5065**	0.9372
HepG2	0.1772	0.1283**	0.7243	0.1250	0.1180*	0.9458
SNU-449	2.273	0.5713***	0.4173	0.4825	0.4117**	0.9962
SNU-387	1.459	0.5063***	0.5743	0.5811	0.4973***	1.087

^aIC₅₀ of doxorubicin concentration in two treatments for 48 h for HCC cells with normal expression of FOXO3a

^bIC₅₀ of doxorubicin concentration in two treatments for 48 h for HCC cells with high expression of FOXO3a.

^*p < 0.05

^**p < 0.01

^***p < 0.001.