Figure 1. MPD in Cbl/Cbl-b DKO mice is cell autonomous and only LSK cells initiate disease.

(A–B) Whole BM cells were transplanted into lethally-irradiated syngeneic WT recipients; PB counts performed after 4 weeks (A) and survival scored up to 16 weeks (B). Data from two experiments are pooled. Dots represent individual mice. (C–D) FACS-sorted subpopulations from WT or Cbl/Cbl-b DKO BM were transplanted with helper cells. (C) MPD (granulocyte count > 10⁴/ml or death before the study was terminated at 16-weeks) after transplantation. (D) PB cell counts at 16-weeks. Data from two experiments are pooled (*p < 0.05).