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. 2015 Mar 25;6(12):10563–10576. doi: 10.18632/oncotarget.3384

Figure 1. Anti-angiogenic activity of iVR1 in vivo.

Figure 1

(A) Chemical structure of iVR1 tetrameric tripeptide that has a calculated molecular mass of 2362.02 g/mol. (B) Schematic representation of the iVR1. L-Cys(Bzl): L-cysteine(S-benzyl); L-Cha, L-cyclohexylalanine. (C) iVR1 inhibited laser-induced CNV in a dose-dependent manner, whereas CP was ineffective. CNV volumes were measured by confocal evaluation of Isolectin B4 staining of RPE-choroid flat mounts. Data are represented as the mean ± SEM (N = 8). *p < 0.0005 and §p < 0.01 compared to vehicle and CP; #p < 0.05 versus CP. (D) Representative pictures of CNV flat mounts. Scale bar: 100 μm.