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. 2015 Mar 25;6(12):10563–10576. doi: 10.18632/oncotarget.3384

Figure 5. Dose-dependent inhibition of macrophage migration and xenograft tumor growth exerted by iVR1.

Figure 5

iVR1, but not CP, was able to inhibit migration of mouse RAW264.7 macrophages (A) and ex vivo peritoneal macrophages (B) stimulated by VEGF-A or PlGF, in a dose-dependent manner. Data are expressed as fold induction with respect to vehicle (DMSO). A, *p < 0.0005 and §p < 0.001 versus CP and VEGF-A or PlGF. B, *p < 0.0005 and §p < 0.05 versus CP. (C) Dose-dependent inhibition of HCT-116 tumor growth exerted by iVR1 delivered at 10 or 25 mg/kg each other day. Bevacizumab (bevaciz) was delivered at 5 mg/kg two times at week. N = 7, *p < 0.001 versus vehicle and CP.