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. 2015 Mar 12;6(12):10592–10603. doi: 10.18632/oncotarget.3547

Figure 6. TLR4 blocking antibody inhibits M2 macrophages polarization to M1 macrophages induced by PA-MSHA.

Figure 6

A, Relative expression of TLR2, TLR4 and TLR6 in CD163+TAMs with PA-MSHA treatment compared to untreated with PA-MSHA in vitro was analyzed by real-time PCR. B, TLR4 expression in CD163+ TAMs after using anti-TLR4 blocking antibody was analyzed by real-time PCR. C, Relative expression of Aginase-1, IL-10, TNF-α, iNOS, CXCL12 in CD163+ macrophages with and without using TLR4 blocking antibody was analyzed by real-time PCR. Untreated = untreated with any PA-MSHA and TLR4 blocking antibody; Treated = treated with PA-MSHA; Anti-TLR4 = treated with PA-MSHA and TLR4 blocking antibody. Results are presented as histogram. * = P<0.05, ** = P<0.01, *** = P<0.001, ns = non-significance.