Table 2. Currently available agents aimed at DUBs discussed in this review.
DUB | Compound | Other targeted DUBs | Reference |
---|---|---|---|
Usp1 | Pimozide ML323 SJB2-043 and SJB3-019A GW7647 |
Usp2, Usp5, Usp7, Usp8, Usp46 - - - |
[87] [88], [89], [90] [91] [87] |
Usp7 | HBX 19,818 and HBX 28,258 P5091 and P22077 Pimozide |
Usp47 - Usp1, Usp2, Usp5, Usp8, Usp46 |
[93] [95], [96], [97] [87] |
Usp10 | Spautin-1 | Usp13 | [77] |
Usp14 | b-AP15 AC17 |
UCHL5 UCHL5 |
[98] [99] |
Usp46 | Pimozide | Usp1, Usp2, Usp5, Usp7, Usp8 | [87] |