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. 2015 Apr 7;6(12):9781–9793. doi: 10.18632/oncotarget.3382

Figure 3. TGF-β promotes EMT via Src activation in NPC cells.

Figure 3

(A) TGF-β-induced NPC cell scattering and morphologic changes in CNE-1 cells were suppressed by SB431542 (TGF-β receptor 1 blocker) or PP2 (Src inhibitor). Scale bar = 50 μm. (B) Wound-healing assay in NPC cells with TGF-β and SB431542 or PP2. Left panel, representative images. Right panel, quantitative data. (C) Transwell assay for NPC cells treating with TGF-β and SB431542 or PP2. (D) Representative Western blots and the semi-quantitative assessments of the EMT marker (E-cadherin, vimentin and β-catenin) and total as well as Tyr416 phosphorylated Src expressions in NPC cells treated with TGF-β and SB431542 or PP2. # P < 0.01, + P < 0.001.