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. 2015 Mar 18;6(12):9794–9806. doi: 10.18632/oncotarget.3400

Figure 6. Effects of Ntn4 or Neo on JAK/Stat, PI3K/Akt, ERK/MAPK signaling.

Figure 6

A–B. Ntn4 silencing down-regulated the expression of MMP2 (A) and up-regulated the expression of TIMP1 (B). Cells were transfected with siRNAs for 48 hours and subjected to western blot with indicated antibodies. C. Neo ablation down-regulated MMP2 and up-regulated TIMP1. D–E. Effect of Ntn4 knockdown (D) and Ntn4 overexpression (E) on phosphorylation of Stat3, Akt, ERk and p38. The phosphorylation level was evaluated by western blot with specific antibodies to p-Stat3, p-Akt, p-ERK and p-p38, respectively. F. Effect of Neo knockdown on p-Stat3, p-Akt, p-ERK and p-p38.