Skip to main content
. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Cancer Res. 2014 Oct 1;74(23):6833–6844. doi: 10.1158/0008-5472.CAN-14-0602-T

Figure 4.

Figure 4

Pathway replication. A, the P38 MAPK pathway containing TGFβR1 that is significant in both the oropharyngeal cancer and cervical cancer GWAS. Significant P values from the oropharyngeal cancer and cervical cancer datasets are listed for each gene. The colors correspond to the dataset in which the genes were significant, as described in the color key. TGFβR1 is the most significant gene in both datasets. B, the comparative significance of all TGFβ-related pathways in the two HPV-associated cancers, oropharyngeal cancer and cervical cancer, and in classic non-HPV–mediated HNSCC, laryngeal cancer. Heatmap color intensity is proportional to the P value or FDR as indicated. Pathway names highlighted in red represent those that include TGFβR1.