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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2015 May 22;26(8):1299–1310. doi: 10.1007/s13361-015-1164-4

Scheme 1.

Scheme 1

Generalized scheme for analysis of variant hemoglobins by MS. Screening may be performed with MALDI ISD. T3 sequencing provides to opportunity for more detailed confirmatory analysis.