Skip to main content
. 2015 May 11;12(4):493–504. doi: 10.1038/cmi.2015.37

Figure 1.

Figure 1.

The autoimmune response towards MCII parallels that to BCII and is initiated in the spleen. (a–d) The number of BCII- and MCII-specific IgM- and IgG-positive B cells was investigated by ELISpot in the spleen and lymph nodes of naïve and mice immunized with BCII for CIA (n = 6–8). (e–f) The serum levels of BCII- and MCII-specific IgM and IgG was measured by ELISA in naïve and BCII-immunized mice (n = 5–27). Data were presented as mean ± SEM and represent two to three independent experiments. The dotted line in e represents the mean antibody response against a control antigen (bovine serum albumin) over time. AFC = antibody-forming cells; BCII = bovine collagen type II; MCII = murine collagen type II; OD = optical density.