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CR1/2-deficient B cells show increased CII reactivity. The number of BCII-specific IgM-positive B cells was investigated by ELISpot in the spleen of naïve and low-dose BCII-immunized WT-, CR1/2-, and FcγRIIb-deficient mice (n = 5–6). Data were presented as mean + SEM and represent seven independent experiments. AFC = antibody-forming cells.
