Figure 1.

Amino acid composition of protein-protein interfaces extracted from 87 high-resolution structures of protein-protein complexes. (A) Fractional overrepresentation of each amino acid residue type and of the four amino acid residue classes (FWY, CILMV, AGPST, and DEHKNQR) in ORD-IDP complexes relative to ORD-ORD complexes. log₂ of the ratios are plotted with positive values indicating overrepresentation in ORD-IDP complexes. (B) Correlation plots of the fractions of the four amino acid residue classes (FWY, CILMV, AGPST, and DEHKNQR) in protein-protein interfaces. Each point represents a protein-protein complex and is colored either red (ORD-ORD) or blue (ORD-IDP).