FIG 1.

Increased Tim-3 expression on CD4⁺ and CD8⁺ T cells in S. japonicum-infected mice. HMCs (A, B, E, and F) and splenic immune cells (C, D, G, and H) from S. japonicum-infected mice were collected at 0, 2, 4, 6, and 8 weeks postinfection, and Tim-3 expression on T cells was detected by flow cytometry. (A, C, E, and G) Representative dot plots of Tim-3 expression on CD3⁺ CD4⁺ T cells (A and C) and CD3⁺ CD8⁺ T cells (E and G). The plots are representative of three independent experiments with five to seven mice in each group per experiment. (B, D, F, and H) Comparisons of the proportions of Tim-3⁺ cells in the CD3⁺ CD4⁺ T cell population (B and D) and in the CD3⁺ CD8⁺ T cell population (F and H) among groups of mice at 0, 2, 4, 6, and 8 weeks postinfection (means ± standard deviations [SD]; *, P < 0.05; **, P < 0.01; ***, P < 0.001).