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. 2015 Jul 8;83(8):3043–3060. doi: 10.1128/IAI.00315-15

TABLE 3.

Cell envelope-associated genes regulated by c-di-GMP

Protein and gene Symbol Descriptiona Fold change in regulationb (WT/Δrrp1)
Putative/known lipoproteins
    bba32 Hypothetical protein NE
    bba60 Surface lipoprotein P27 10.14
    bbm28 mlpF MlpF 7.63
    bbq35 mlpJ MlpJ 6.91
    bbs30 mlpC MlpC 6.59
    bbo39 erpL ErpL 6.05
    bbq03 Lipoprotein 6.04
    bbp28 mlpA MlpA 5.99
    bbb27 Hypothetical protein 5.89
    bbo28 mlpG MlpG 5.52
    bbs41 erpG ErpG 5.12
    bbb08 Hypothetical protein 4.58
    bbl40 erpO ErpO 4.52
    bbl28 mlpH MlpH 4.30
    bbi16 Hypothetical protein 4.01
    bbm27 revA Rev protein 3.96
    bbo40 erpM ErpM 3.94
    bbp39 erpB ErpB 3.90
    bbn28 mlpI MlpI 3.85
    bbp38 erpA ErpA 3.76
    bbl39 erpN ErpN 3.14
    bbn38 erpP ErpP 3.02
    bbn39 erpQ ErpQ 2.99
    bbk48 Immunogenic protein P37 2.94
    bba04 S2 antigen 2.94
    bba07 chpA1 ChpA1 protein 2.93
    bbb16 oppAIV ABC-type oligopeptide transport (Opp) system periplasmic solute-binding protein component OppAIV 2.80
    bba05 S1 antigen 2.77
    bba57 Lipoprotein 2.68
    bbb09 Hypothetical protein 2.65
    bba73 P35 antigen, putative 2.60
    bbq47 erpX ErpX 2.60
    bba69 Hypothetical protein 2.57
    bbe31 P35 antigen, putative 2.53
    bba66 Lipoprotein 2.46
    bbr42 erpY ErpY 2.45
    bbi42 Hypothetical protein 2.41
    bb0323 LysM domain-containing protein 2.33
    bba62 lp6.6 Lipoprotein 2.31
    bbk49 Hypothetical protein 2.30
    bbr28 mlpD MlpD 2.23
    bbp27 revA Rev protein 2.23
    bbk50 P37 immunogenic protein 2.14
    bba59 Lipoprotein 2.10
    bba65 Lipoprotein 2.09
    bb0689 Hypothetical protein 2.09
    bba34 oppAV ABC-type oligopeptide transport system (Opp) periplasmic solute-binding protein protein component OppAV −2.29
    bb0298 TPR domain-containing protein −2.08
    bb0542 TPR domain-containing protein −2.03
Inner membrane-associated proteins
    bb0240 glpF Glycerol uptake facilitator 11.94
    bbq34 bdrW BdrW 6.66
    bbs29 bdrF BdrF 3.46
    bbn27 bdrR BdrR 3.38
    bbb04 chbB PTS system, chitobiose-specific EIIC component 3.10
    bbb03 resT Telomere resolvase 3.01
    bbl35 bdrO BdrO 2.61
    bb0409 Hypothetical protein 2.58
    bb0591 Competence locus E, putative 2.56
    bbp34 bdrA BdrA 2.43
    bb0631 Hypothetical protein 2.31
    bbq42 bdrV BdrV 2.23
    bbs37 bdrE BdrE 2.22
    bb0629 fruA-2 PTS system, mannose-specific EIIABC component 2.21
    bbb29 malX-2 PTS system, GlcNAc/glucose-specific EIIABC component 2.19
    bbi38 Hypothetical protein 2.07
    bbh13 Hypothetical protein 2.04
    bbj41 P35 antigen, putative 2.02
    bb0373 Hypothetical protein −6.37
    bb0580 Conserved hypothetical integral membrane protein −6.13
    bb0694 ffh Signal recognition particle protein −3.44
    bb0397 Putative inner membrane protein −2.90
    bb0442 Putative membrane protein insertase −2.40
    bb0146 proV Glycine betaine, l-proline ABC transporter, ATP-binding protein −2.36
    bb0116 malX-1 PTS system, GlcNAc/glucose-specific EIIABC component −2.27
    bb0754 ABC transporter, ATP-binding protein −2.13
    bb0170 Hypothetical protein −2.07
    bb0089 Hypothetical protein −2.04
Putative outer membrane-spanning and periplasmic proteins
    bba74 bba74 Outer membrane-associated periplasmic protein 7.51
    bbi31 P13 porin paralog 5.21
    bbq06 P13 porin paralog 4.33
    bbh41 P13 porin paralog 3.77
    bba52 Putative periplasmic protein 2.81
    bb0418 dipA Dicarboxylate-specific porin A 2.47
    bb0624 Hypothetical protein −2.25
    bb0794 Hypothetical protein −2.06
a

Annotations and gene product descriptions are based on those provided by the Spirochetes Genome Browser (sgb.fli-leibniz.de).

b

Fold regulation based on RNA-Seq. See Table S2 in the supplemental material for the complete data set. NE, not expressed by the B. burgdorferi Δrrp1 mutant.