TABLE 1.
Volunteer (gender)a | Observation period (no. of days) | Strainb | Dose(s) (CFU)c | No. of initial papules | Final outcome of papules |
|
---|---|---|---|---|---|---|
No. of pustules | No. of papules that resolved | |||||
454 (F) | 7 | P | 82 | 2 | 0 | 2 |
M | 52–207 | 2 | 0 | 2 | ||
455 (M) | 9 | P | 82 | 3 | 1 | 2 |
M | 52–207 | 3 | 1 | 2 | ||
456 (F) | 5 | P | 82 | 3 | 0 | 3 |
M | 52–207 | 2 | 0 | 2 | ||
457 (F) | 7 | P | 150 | 3 | 3 | 0 |
M | 87–348 | 3 | 1 | 2 | ||
458 (F) | 5 | P | 150 | 2 | 0 | 2 |
M | 87–348 | 1 | 0 | 1 | ||
459 (M) | 8 | P | 77 | 3 | 1 | 2 |
M | 137 | 3 | 1 | 2 | ||
460 (F) | 12 | P | 77 | 3 | 3 | 0 |
M | 137 | 3 | 0 | 3 |
Volunteers 454, 455, and 456 were inoculated in the first iteration. Volunteers 457 and 458 were inoculated in the second iteration. Volunteers 459 and 460 were inoculated in the third iteration. F, female; M, male.
P, parent strain 35000HP; M, mutant strain 35000HPΔdksA.
Doses (single doses) inoculated at three sites. 52–207, one dose each of 52, 104, and 207 CFU; 87–348, one dose each of 87, 174, and 348 CFU.