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. 2015 May 5;5(2):758–774. doi: 10.3390/biom5020758

Figure 1.

Figure 1

Schematic representation of the HPV16 genome. Boxes indicate open reading frames. HPV16 early and late promoters p97 and p670, respectively, early and late polyadenylation signals pAE and pAL, respectively, and 5'- (SD) and 3'- (SA) splice sites are indicated. A subset of HPV16 mRNAs initiating at the p670 promoter is shown and splicing regulatory elements are indicated. Filled boxes represent positive RNA elements that enhance usage of splice sites or polyA signals and white boxes represent suppressive RNA elements that inhibit splice sites or polyA sites. Examples of alternatively spliced HPV16 mRNAs initiated at early (p97) and late (p670) promoters and terminated at early (pAE) or late (pAL) polyadenylation signals are displayed.