Table 1.
Summary of cyclophilins involved in RNA-mediated gene expression.
| Name in Review | Other Names | PDB Code/s | Proline Isomerase Activity? | Interacting Proteins in RNA Metabolism | Other Domains Present |
|---|---|---|---|---|---|
| PPIL1 | CYPL1, hCyPX, CGI-124 | 1XWN (NMR) 2K7N (NMR) 2X7K (X-ray) | Yes | Ski-interacting protein (SKIP) | None |
| PPIL2 | CYC4, Cyp60, UBOX7, Cyp58 | 1ZKC (ring-domain) | No | unknown | N-terminal U-box (E3 ligase) |
| PPIL3b | CyPJ | 2OJU (X-ray) 2OK3 (X-ray) 1XYH (X-ray) | Unknown | Unknown protein in the U2snRNP | None |
| PPIE | CYP33, CYP-33 | 3UCH (X-ray PPIase) 2CQB (NMR-RRM) 2KYX (NMR-RRM) 3LPY (X-ray RRM) 3MDF (X-ray RRM) 2R99 (X-ray PPIase) 1ZMF (X-ray PPIase) 2KU7 (MLL1 PHD3-Cyp33 RRM chimeric protein) | Yes | MLL1 histone methyltransferase | N-terminal RRM |
| PPIL4 | CyP57 | None | Yes | RNA Pol II CTD | C-terminal RRM |
| PPWD1 | CyP73 | 2A2N (X-ray PPIase) | Yes | Unknown | WD40 repeats |
| PPIH | Snu-Cyp20, USA-Cyp, CyPH | 1MZW (X-ray PPIase) | Yes | hPrp4; hPrp18 | None |
| PPIG | SR-Cyp, CARS-Cyp, CYPG, Matrin-CyP (rat) | 2GW2 (X-ray PPIase) | Yes | Clk kinase; RNA Pol II CTD | N-terminal RS domains; Nopp140 repeats |