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. 2015 Jul 7;6(4):408–419. doi: 10.3945/an.114.008052

FIGURE 3.

FIGURE 3

Molecular mechanisms mediating the anticancer effect of genistein: downregulation/suppression, inhibition, enhancement. AP-1, activator protein 1; Bax, Bcl-2–associated X protein; Bcl-2, B cell lymphoma 2; EGFR, epidermal growth factor receptor; IκB, inhibitor of NF-κB; KIF20A, kinesin-like protein 20A; PI3K/Akt, phosphoinositide 3 kinase/Akt; TRAIL, tumor necrosis factor–related apoptosis-inducing ligand; TRAIL R, TRAIL death receptors; Wnt/β-catenin, Wingless and integration 1 β-catenin.