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. Author manuscript; available in PMC: 2015 Jul 9.
Published in final edited form as: Behav Brain Res. 2014 Nov 15;280:160–171. doi: 10.1016/j.bbr.2014.11.014

Fig. 4.

Fig. 4

Effects of SKF-82958 and quinpirole on distance moved (m) in NT+/+ and NT−/− mice. Data are expressed as mean distance moved (m)/30 min time period ± S.E.M. 0.3 mg/kg SKF-82958 significantly increased locomotion at the 0–30 min timepoint (A), and 1 mg/kg SKF-82958 significantly increased locomotion at the 0–30 min and 30–60 min timepoints (B), but NT knockout did not significantly affect SKF-82958-induced hyperlocomotion at either dose. (C) 0.1 mg/kg quinpirole significantly decreased locomotion similarly in both NT+/+ and NT−/− mice at the 0–30 min timepoint. (D) 1 mg/kg quinpirole significantly decreased locomotion at the 30–60 min timepoint and 60–90 min timepoint in NT+/+ mice (**p < 0.01, drug compared to saline control within genotype), but the hypolocomotor effect of 1 mg/kg was absent in NT−/− mice (n.s., p > 0.05).