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. 2015 Jul 9;5:12063. doi: 10.1038/srep12063

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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This network contains 761 drug target genes (square) and 148 drugs (circle) that either down-regulate or up-regulate STAT1 expression. The edges denote the drug-target interactions collected from DrugBank (v3.0), the Therapeutic Target Database (TTD), and the PharmGKB database. Genes were color-coded based on the STAT1 experimentally validated targeted genes (validated targets, red squares), computationally predicted STAT1 target genes (predicted targets, yellow squares), and unknown STAT1 target genes (non-targets, cyan squares). All drugs were grouped using the anatomical therapeutic chemical (ATC) classification system codes. This graph was visualized using Cytoscape v2.8.3 (http://www.cytoscape.org/).