Table 10.
Microscopic findings in the nasal cavity and larynx of male and female rats 24 h and 90 days after a 90-day exposure to Graphistrength© C100
| Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|
| Target concentration (mg/m3) | 0 | 0.05 | 0.25 | 5.0 | 0 | 0.05 | 0.25 | 5.0 |
| Number examined | 10/10 | 10/0 | 10/10 | 10/10 | 10/10 | 10/0 | 10/10 | 10/10 |
| (24 h/90 days) | ||||||||
| Nasal cavity epithelium, eosinophilic globules | ||||||||
| minimal | 4/2 | - | 2/3 | 2/6 | -/3 | - | 3/2 | 1/4 |
| slight | -/1 | - | - | 3/2 | - | - | - | 6/2 |
| moderate | - | - | - | 5/2 | - | - | - | 2/3 |
| Mean severitya | 0.4/0.4 | - | 0.2/0.3 | 2.3/1.6 | -/0.3 | - | 0.3/0.2 | 1.9/1.7 |
| Larynx, squamous metaplasia | ||||||||
| minimal | - | - | 2/- | 4/- | - | - | - | 5/1 |
| Mean severitya | - | - | 0.2/- | 0.4/- | - | - | - | 0.5/0.1 |
Histopathological findings were graded in severity using a five point system of minimal (grade 1), slight (grade 2), moderate (grade 3), marked (grade 4) or severe (grade 5)a: mean severity is ∑ number of animals x severity / number of examined organs in the group
a: mean severity is ∑ number of animals x severity / number of examined organs in the group - : no animal affected