Table 4.
Cell analysis in the BALF of male and female rats 24 h and 90 days after a 90-day exposure to Graphistrength© C100
| Concentration (mg/m3) | Total cell Count | Viability | Macrophages | Eosinophils | Lymphocytes | Neutrophils | Epithelial cells |
|---|---|---|---|---|---|---|---|
| 106 | % | % | % | % | % | ||
| MALE | |||||||
| 24 h post exposure | |||||||
| 0 | 1.74 | 84.40 | 93.9 | 0.0 | 4.4 | 1.5 | 0.1 |
| 0.05 | 1.62 | 84.65 | 91.8 | 0.0 | 5.1 | 3.1 | 0.0 |
| 0.25 | 2.24 | 89.00 | 64.8** | 0.0 | 9.7* | 25.2** | 0.3 |
| 5.0 | 2.01 | 88.00 | 31.5** | 0.0 | 12.8** | 55.6** | 0.1 |
| 90 days post exposure | |||||||
| 0 | 1.80 | 90.10 | 96.5 | 0.0 | 2.1 | 1.2 | 0.2 |
| 0.05 | 2.21 | 91.35 | 96.9 | 0.0 | 1.9 | 0.9 | 0.3 |
| 0.25 | 2.85* | 91.35 | 91.2 | 0.1 | 3.8 | 4.7 | 0.3 |
| 5.0 | 6.23** | 89.86 | 44.6** | 0.0 | 20.4** | 39.8** | 0.3 |
| FEMALE | |||||||
| 24 h post exposure | |||||||
| 0 | 1.67 | 91.80 | 96.9 | 0.0 | 2.5 | 0.4 | 0.1 |
| 0.05 | 1.27 | 92.55 | 94.5 | 0.0 | 4.4 | 1.0 | 0.1 |
| 0.25 | 2.16 | 92.55 | 80.9** | 0.0 | 4.1 | 15.0** | 0.0 |
| 5.0 | 2.98** | 95.50 | 34.7** | 0.0 | 11.5** | 53.8** | 0.0 |
| 90 days post exposure | |||||||
| 0 | 1.67 | 86.39 | 96.1 | 0.0 | 3.1 | 0.5 | 0.2 |
| 0.05 | 1.66 | 85.40 | 95.8 | 0.0 | 3.4 | 0.8 | 0.0 |
| 0.25 | 1.86 | 87.55 | 93.9 | 0.0 | 3.3 | 2.8 | 0.0 |
| 5.0 | 4.02** | 88.80 | 46.7** | 0.0 | 13.0** | 40.1** | 0.0 |
* p < 0.05, ** p < 0.01; statistical significant differences to controls