Table 1.

The Unmet Needs in Treatment of Gastroesophageal Reflux Disease

1	Healing and symptom’s response in advanced erosive esophagitis
2	Nonerosive reflux disease
3	Postprandial heartburn
4	Nighttime heartburn
5	Maintenance treatment in erosive esophagitis
6	On-demand/intermittent therapy
7	Refractory GERD
8	Atypical manifestations of GERD
9	Extraesophageal manifestations of GERD
10	Dependency on food for efficacy
11	Chronic PPI treatment
12	Barrett’s esophagus
13	Post-bariatric surgery GERD

GERD, gastroesophageal reflux disease; PPI, proton pump inhibitor.