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. 2015 Jul 3;21(3):352–360. doi: 10.5056/jnm14112

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© 2015 The Korean Society of Neurogastroenterology and Motility

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Effect of SKI3246 on upper gastrointestinal (GI) transit time of guinea pigs. (A) Effect of SKI3246 on upper GI transit time of guinea pigs in the native condition (n = 6). SKI3246 had no effect on charcoal transit time at 3 dose levels as compared with the control group by Mann-Whitney test. (B) Effect of SKI3246 on upper GI transit time in TRH-pretreated guinea pigs (control groups, n = 6; TRH pretreatment control groups, n = 5; SKI3246 treated groups, n = 7). Guinea pigs pretreated with TRH (100 μg/kg) showed no difference in charcoal transit compared with the control group. As compared with the control group, SKI3246 showed no effect on charcoal transit at 3 different dose levels among groups pretreated with TRH. (C) Effect of SKI3246 on upper GI transit in mustard oil (MO)-pretreated guinea pigs (control groups, n = 6; MO pretreatment control groups, n = 5; SKI3246 treated groups, n = 7). Groups pretreated with MO (10 mg/kg) displayed significantly elongated charcoal transit compared with the control group (P = 0.009). Among MO-pretreated groups, SKI3246 had no effect on charcoal transit at lower doses compared with control group. At a higher dose (600 mg/kg), however, SKI3246 significantly shortened the charcoal transit (P = 0.030). The error bars indicate standard deviation.