Table 1.

Characteristics of study participants by genotype for PONS1 Q192R polymorphism (N = 3,266)

Variable	Means or [N] % (95% CI) by genotype			P heterogeneitya
	QQ N = 1669	QR N = 1326	RR N = 271
Dichotomous variables
Myocardial infarction (MI)	[53] 3.2 (2.4, 4.3)	[46] 3.5 (2.6, 4.8)	[12] 4.4 (2.3, 7.6)	0.51
Angina (but no history of MI)	[186] 11.1 (9.7, 12.8)	[165] 12.4 (10.7, 14.3)	[18] 6.6 (4.0, 10.3)	0.13
Any CHD (MI or angina)	[239] 14.3 (12.7, 16.1)	[211] 15.9 (14.1, 18.0)	[30] 11.1 (7.6, 15.4)	0.14
Diabetes at baseline	[75] 4.5 (3.6, 5.6)	[70] 5.3 (4.3, 6.7)	[12] 4.4 (2.5, 7.6)	0.61
Current smoker	[189] 11.3 (9.9, 12.9)	[163] 12.3 (10.6, 14.1)	[22] 8.1 (5.4, 11.9)	0.12
Ever smoker	[746] 44.6 (42.2, 47.0)	[596] 44.9 (42.3, 47.6)	[116] 42.9 (37.1, 48.8)	0.82
Adult manual social class	[964] 57.8 (55.4, 60.2)	[725] 54.7 (52.0, 57.3)	[157] 57.9 (51.9, 63.6)	0.20
Childhood manual social class	[1334] 79.9 (77.9, 81.8)	[1075] 81.1 (78.9, 83.1)	[219] 81.0 (75.9, 85.2)	0.72
On statin	[126] 7.5 (6.4, 8.9)	[95] 6.9 (5.6, 8.3)	[25] 9.2 (6.3, 13.2)	0.41
Continuous variables
Age	68.8 (68.6, 69.1)	68.8 (68.5, 69.1)	68.9 (68.3, 68.3)	0.91
HOMAc	1.64 (1.59, 1.70)	1.72 (1.66, 1.79)	1.69 (1.56, 1.82)	0.15
Total cholesterol	6.64 (6.58, 6.70)	6.65 (6.58, 6.72)	6.61 (6.46, 6.75)	0.85
HDLc	1.65 (1.63, 1.67)	1.65 (1.63, 1.68)	1.70 (1.65, 1.76)	0.18
LDLc	4.15 (4.09, 4.20)	4.15 (4.09, 4.21)	4.02 (3.89, 4.16)	0.21
Triglyceridesc	1.67 (1.64, 1.71)	1.69 (1.65, 1.73)	1.71 (1.62, 1.81)	0.73
Systolic BP	148.3 (147.1, 149.5)	146.0 (144.6, 147.3)	150.4 (147.4, 153.4)	0.006
Diastolic BP	79.9 (79.3, 80.4)	78.9 (78.3, 79.6)	80.3 (78.9, 81.8)	0.05
BMI	27.6 (27.3, 27.8)	27.6 (27.4, 27.9)	27.6 (27.0, 28.2)	0.96
WHR	0.817 (0.814, 0.821)	0.821 (0.817, 0.824)	0.826 (0.818, 0.834)	0.11

^a χ² for dichotomous variables and ANOVA for continuous variables ^bOccurrence of a new CHD event (death from CHD, new diagnosis of MI / angina, new CABG or angioplasty). All other characteristics are from baseline measures ^cGeometric means