Table 2.

Hazard ratios in multivariate analysis (MVA) for (a) OS and (b) PFS

	a) Hazard ratios for OS		b) Hazard ratios for PFS
Parameter	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Age	1.00 (0.99, 1.02)	0.701	1.00 (0.98, 1.01)	0.73
Sex (female)	0.77 (0.50, 1.18)	0.228	0.90 (0.60, 1.34)	0.598
Karnofsky Index	0.99 (0.98, 1.01)	0.514	1.00 (0.98, 1.01)	0.575
T3	1.54 (0.95, 2.49)	0.005	1.51 (0.96, 2.36)	0.006
T4	2.43 (1.39, 4.22)		2.32 (1.37, 3.94)
N1	1.38 (0.89, 2.14)	0.293	1.24 (0.75, 1.87)	0.601
N2/3	1.46 (0.87, 2.46)		1.24 (0.75, 2.03)
M1	1.56 (1.09, 2.23)	0.015	1.69 (1.19, 2.39)	0.003
G3/4	1.06 (0.78, 1.45)	0.709	1.10 (0.81, 1.49)	0.534
Initial hemoglobin	0.96 (0.89, 1.03)	0.255	0.95 (0.88, 1.02)	0.136
Localization	1.00 (0.98, 1.03)	0.711	1.00 (0.97, 1.02)	0.83
Histologic subtype (AC)	0.86 (0.56, 1.32)	0.499	0.95 (0.62, 1.45)	0.812
Total radiation dose (>55 Gy)	0.68 (0.49, 0.94)	0.019	0.69 (0.51, 0.95)	0.022
Chemotherapy (yes)	0.38 (0.27, 0.54)	<0.001	0.44 (0.31, 0.63)	<0.001
Immunotherapy (Cetuximab) (yes)	0.45 (0.24, 0.83)	0.011	0.61 (0.34, 1.09)	0.097