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Adoptive transfer of CXCR3+ leukocytes partially reverses the fibrotic response. CXCR3–/– mice were injected intravenously with CXCR3+ or CXCR3–/– leukocytes isolated from spleen and LNs. Following bleomycin-induced lung injury, CXCR3+ recruitment to the lung on day 7 (A), IFN-γ production at day 1 (B), and hydroxyproline content on day 21 (C) were analyzed. P values are indicated.
