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In vitro activity of c-Src and SHP2 in the indicated cell lines A, B. c-SRC and SHP2 were immunopurified from lysates of A375 derivative cell lines and employed in a colorimetric activity assay. The graph represents average measurements from three independent experiments, and error bars represent the SD. *P < 0.05, **P < 0.01, ***P < 0.001.
