Table 3.
Comparison between Notch1 gene methylation and patient clinicopathological parameters
| Parameters | N | Notch1 (Mean methylation %) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Oveall | CpG_1.2 | CpG_3 | CpG_4.5 | CpG_8 | CpG_10.11 | CpG_12.13 | CpG_14.15.16 | CpG_18 | ||
| Lymph node metastasis | ||||||||||
| - (LNN) | 39 | 15.24* | 11.85 | 21.80 | 21.00* | 21.14 | 7.13* | 16.46 | 11.97* | 15.71 |
| + (LNP) | 34 | 12.02 | 7.09 | 14.61 | 15.68 | 19.20 | 3.36 | 14.31 | 6.24 | 14.48 |
| TNM stage | ||||||||||
| I | 10 | 19.94* | 13.40 | 18.60 | 22.90 | 19.00 | 7.40 | 16.70 | 16.80* | 24.80* |
| II | 29 | 13.57 | 8.82 | 15.82 | 20.21 | 18.07 | 5.67 | 15.38 | 9.82 | 17.00 |
| III | 34 | 12.37 | 7.48 | 13.25 | 19.45 | 17.23 | 3.61 | 13.92 | 7.86 | 13.96 |
| Histological grade | ||||||||||
| 1 | 8 | 17.69* | 17.88* | 18.38 | 28.50 | 19.75 | 7.75 | 28.25* | 12.00 | 17.25 |
| 2 | 57 | 13.26 | 8.70 | 14.64 | 19.61 | 19.12 | 5.09 | 15.20 | 9.21 | 14.91 |
| 3 | 8 | 12.36 | 5.38 | 11.50 | 21.38 | 24.29 | 2.50 | 12.25 | 8.63 | 14.71 |
| Receptor status | ||||||||||
| ER(+)/PR(+) Her2(-) | 52 | 20.33* | 11.33 | 24.69* | 22.20 | 23.67* | 6.17 | 21.00 | 17.64* | 26.17 |
| ER(-) PR(-) Her2(+) | 12 | 14.09 | 9.83 | 18.60 | 20.77 | 16.71 | 6.10 | 20.91 | 8.27 | 24.27 |
*
P<0.05.