Figure 1.

Signaling network in regulation of glucose uptake and DNA repair in cancer cells. This scheme displays prominent features of glycolysis, PI3K/Akt/mTor signaling and DNA damage response. It represents an idea how these pathways might be connected, and how cell metabolism might respond to genotoxic stress (20, 34). Activation and inhibition are represented by arrows and bars, respectively. ATM Ataxia telangiectasia mutated, DNA-PK DNA-dependent protein kinase, HK hexokinase, DSB double-strand break, GF growth factor, Glc glucose, GLUT glucose transporter, G-6-P glucose-6-phosphate, HR homologous recombination, NHEJ non-homologous end joining, mTOR mammalian target of rapamycin, PI3K phosphatidylinositol-4,5-bisphosphate 3-kinase, Pyr pyruvate, TCA cycle tricarboxylic acid cycle.